NFL Week 13 Picks 2025: Florio vs. Simms | Expert Predictions & Analysis (2026)

PFT's Week 13 2025 NFL picks: Florio vs. Simms - NBC Sports

After 12 weeks, the race is neck-and-neck.

With Simms' 11-3 record last week and my 10-4, we're both sitting at 119-58-1 for the season.

Against the spread, I had a strong week with 9-4-1, while Simms was 6-7-1. For the year, I'm at 95-81-2, and Simms is at 87-89-2.

Last week's picks included my daring prediction that the Cowboys would beat the Eagles 24-21. I've even managed to predict the exact score of three games this season!

We disagree on three games this week, including two of the three Thanksgiving games.

Scroll down for all the Week 13 picks.

Packers at Lions (-2.5)

The loser of this game will be one step closer to missing the playoffs. If the Lions rely on Jahmyr Gibbs, they might just pull it off.

Florio's pick: Lions 28, Packers 20.

Simms' pick: Packers 24, Lions 23.

Chiefs (-3.5) at Cowboys

The Dallas Texans-Cowboys reunion could be a thrilling game and potentially the most-watched regular-season game ever.

Florio's pick: Cowboys 34, Chiefs 31.

Simms' pick: Chiefs 31, Cowboys 24.

Bengals at Ravens (-7)

Joe Burrow is back, but it might not be enough.

Florio's pick: Ravens 27, Bengals 24.

Simms' pick: Ravens 27, Bengals 17.

Bears at Eagles (-7)

Chicago's schedule is about to get a lot tougher, starting with this game.

Florio's pick: Eagles 20, Bears 14.

Simms' pick: Eagles 30, Bears 20.

Rams (-10) at Panthers

The Rams remain the league's top team.

Florio's pick: Rams 30, Panthers 17.

Simms' pick: Rams 31, Panthers 17.

49ers (-4.5) at Browns

Christian McCaffrey is the key for the 49ers.

Florio's pick: 49ers 24, Browns 20.

Simms' pick: 49ers 17, Browns 9.

Texans at Colts (-4.5)

The Colts need to get back on track after squandering a double-digit lead in Kansas City. The Texans won't be an easy beat.

Florio's pick: Colts 17, Texans 13.

Simms' pick: Texans 23, Colts 20.

Saints at Dolphins (-6)

The effort to save Mike McDaniel's job continues.

Florio's pick: Dolphins 27, Saints 13.

Simms' pick: Dolphins 24, Saints 16.

Falcons (-2.5) at Jets

The Jets are capable of beating an Atlanta team that isn't consistently good enough.

Florio's pick: Jets 28, Falcons 23.

Simms' pick: Jets 20, Falcons 17.

Cardinals at Buccaneers (-3)

The Bucs desperately need a win. The Cardinals give them a chance.

Florio's pick: Buccaneers 31, Cardinals 20.

Simms' pick: Buccaneers 28, Cardinals 24.

Jaguars (-6.5) at Titans

The Jaguars are just good enough to overcome their inconsistent play.

Florio's pick: Jaguars 20, Titans 17.

Simms' pick: Jaguars 31, Titans 14.

Vikings at Seahawks (-11.5)

Sam Darnold's revenge.

Florio's pick: Seahawks 34, Vikings 20.

Simms' pick: Seahawks 30, Vikings 13.

Raiders at Chargers (-10)

After a blowout loss to the Jaguars, the Chargers will make this another long day for the Raiders.

Florio's pick: Chargers 31, Raiders 17.

Simms' pick: Chargers 30, Raiders 17.

Bills (-3.5) at Steelers

The Bills can't afford to lose another one. The Steelers are facing reality.

Florio's pick: Bills 30, Steelers 20.

Simms' pick: Bills 27, Steelers 20.

Broncos (-6.5) at Commanders

The Broncos will play it safe before eating just enough to win.

Florio's pick: Broncos 20, Commanders 16.

Simms' pick: Broncos 30, Commanders 14.

Giants at Patriots (-7)

Eli Manning isn't walking through that door.

Florio's pick: Patriots 34, Giants 24.

Simms' pick: Patriots 38, Giants 20.

NFL Week 13 Picks 2025: Florio vs. Simms | Expert Predictions & Analysis (2026)

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